I'm reminded again why some people look at handloading and despair. I was looking at .22 Hornet loads, which led to looking at .22 K-Hornet(interesting history, there), which led to comparing which led to a lot of time wondering "What the hell?"
For K-Hornet instance, using a 45-grain bullet, Hodgdon shows H110 loads 11.5 to 12.4 grains. Lyman manual shows 10.0 to 11.2 grains.
With Lil' Gun, Hodgdon shows 12.0 to 13.2 grains, Lyman shows 9.1 to 10.2 grains.
That's a LOT of difference. And which one should you follow?
May be an extreme example, but you can find some big differences in charges for the same powder from different sources.